[ - ] "DETECTION OF OPHIDIOMYCES OPHIODIICOLA IN TWO CAPTIVE BOCOURT WATER SNAKES"
Journal of Zoo and Wildlife Medicine 49(1):p219–222,2018
(Pierre Picquet, D.V.M., Kim O. Heckers, Dr. med. vet., Ekaterina Kolesnik, med. vet., Anton Heusinger, Dr. med. vet., and Rachel E. Marschang, Ph.D., Dr. med. vet., Dip. E.C.Z.M. (Herpetology)Pierre Picquet, D.V.M., Kim O. Heckers, Dr. med. vet., Ekaterina Kolesnik, med. vet., Anton Heusinger, Dr. med. vet., and Rachel E. Marschang, Ph.D., Dr. med. vet., Dip. E.C.Z.M. (Herpetology))
Two captive Bocourt water snakes (Subsessor bocourti) presented with chronic white skin lesions on their heads; Ophidiomyces ophiodiicola was identified by culture and polymerase chain reaction (PCR) in skin scrapings from both snakes. Histopathology performed in one Bocourt water snake revealed fungal hyphae in epidermal structures of lesions. One Pueblan milk snake (Lampropeltis triangulum campbelli) from the same zoologic institution presented with yellow crusts and white blisters on its body, from which O. ophiodiicola was identified by culture and PCR. Two of the three snakes apparently recovered from lesions after multiple natural sheds, whereas the third snake died. This is the first report of O. ophiodiicola infection in Bocourt water snakes and in a Pueblan milk snake, as well as the first report of O. ophiodiicola in France.
[ - ] "A novel MLPH variant in dogs with coat colour dilution"
Animal Genetics, Volume 49, Issue 1,p.1-4 DOI: 10.1111/age.12632
(A. Bauer, A. Kehl, V. Jagannathan, T. Leeb)
Coat colour dilution may be the result of altered melanosome transport in melanocytes. Loss-of-function variants in the melanophilin gene (MLPH) cause a recessively inherited form of coat colour dilution in many mammalian and avian species including the dog. MLPH corresponds to the D locus in many domestic animals, and recessive alleles at this locus are frequently denoted with d. In this study, we investigated dilute coloured Chow Chows whose coat colour could not be explained by their genotype at the previously known MLPH:c.–22G>A variant. Whole genome sequencing of such a dilute Chow Chow revealed another variant in the MLPH gene: MLPH:c.705G>C. We propose to designate the corresponding mutant alleles at these two variants d1 and d2. We performed an association study in a cohort of 15 dilute and 28 non-dilute Chow Chows. The dilute dogs were all either compound heterozygous d1/d2 or homozygous d2/d2, whereas the non-dilute dogs carried at least one wildtype allele D. The d2 allele did not occur in 417 dogs from diverse other breeds. However, when we genotyped a Sloughi family, in which a dilute coloured puppy had been born out of non-dilute parents, we again observed perfect co-segregation of the newly discovered d2 allele with coat colour dilution. Finally, we identified a blue Thai Ridgeback with the d1/d2 genotype. Thus, our data identify the MLPH:c.705G>C as a variant explaining a second canine dilution allele. Although relatively rare overall, this d2 allele is segregating in at least three dog breeds, Chow Chows, Sloughis and Thai Ridgebacks.
[ - ] "Gastrointestinal B-lymphoblastic lymphoma in a dog:a case report"
Veterinarni Medicina, 63, 2018 (01): 40–49
(P. Borska, R. Husnik, P. Fictum, A. Kehl, L. Leva, M. Faldyna)
A four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy were performed. Histological examination revealed a high-grade lymphoblastic lymphoma, flow cytometric analysis detected malignant cells of the immature B phenotype. PCR for antigen receptor rearrangement confirmed IgH monoclonality pointing together with immunophenotyping to B-cell lymphoma. The dog was treated using a multi-agent chemotherapy protocol. The overall survival time was 487 days. This was an unusual case of primary gastrointestinal B-lymphoblastic lymphoma in a dog with survival equivalent to that of the multicentric form.
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